EMD-72484

Single-particle
2.81 Å
EMD-72484
3D View Gallery
Deposition: 03/09/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72484

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y4j summary report (pdf.gz) Map-9y4j FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM Structure of human MDA5 with dsRNA (one protein subunit on dsRNA)

EMD-72484

Single-particle
2.81 Å
EMD-72484
3D View Gallery
Deposition: 03/09/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, in vitro transcription vector pT7-Fluc(deltai)
Sample: CryoEM structure of MDA5 binds to dsRNA in presence of AMPPNP - one protein subunit on dsRNA
Fitted models: 9y4j

Deposition Authors: Xu L , Chung K , Pyle A

Unraveling the molecular basis for MDA5 T331I disease-linked mutation
Xu L , Chung K , Guo R, Pan A, Pyle AM
To Be Published
Grant Support: