EMD-72393

Single-particle
5.1 Å
EMD-72393
3D View Gallery
Deposition: 28/08/2025
Map released: 06/05/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72393

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y0h summary report (pdf.gz) Map-9y0h FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Insulin Degrading Enzyme Time-resolved O/O state

EMD-72393

Single-particle
5.1 Å
EMD-72393
3D View Gallery
Deposition: 28/08/2025
Map released: 06/05/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cysteine-free Insulin-degrading enzyme
Fitted models: 9y0h

Deposition Authors: Mancl JM, Tang WJ
Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity.
Mancl JM, Liang WG, Bayhi NL, Wei H, Budell WC, Mendez JH, Sosnick TR, Carragher B, Potter CS, Tang WJ
(2026) eLife , 14
PUBMED: 42253225
DOI: doi:10.7554/eLife.105761
ISSN: 2050-084X