EMD-72386

Single-particle
2.74 Å
EMD-72386
3D View Gallery
Deposition: 28/08/2025
Map released: 29/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72386

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y06 summary report (pdf.gz) Map-9y06 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human VCP/p97-T122P mutant bound to ADP

EMD-72386

Single-particle
2.74 Å
EMD-72386
3D View Gallery
Deposition: 28/08/2025
Map released: 29/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: VCP/p97 T122P mutant bound to ADP
Fitted models: 9y06

Deposition Authors: Lehman A, Ahmed S, Mohajeri A, Yang GX, Berezuk AM, Mannar D, Cholak S, Tuttle KS, Bennett JT, Magno JA, Hannibal M, Kovacevic G, Kuburovic V, Lewis MES, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS
Mutations in VCP cause Adams-Oliver syndrome with or without pulmonary hypertension.
Lehman A, Ahmed S, Mohajeri A, Berezuk AM, Mannar D, Cholak S, Tuttle KS, Bennett JT, Aparecida Magno J, Hannibal M, Kovacevic G, Kuburovic V, Suzanne Lewis ME, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS
(2026) Genet Med , 102579 - 102579
PUBMED: 41979051
DOI: doi:10.1016/j.gim.2026.102579
ISSN: 1530-0366