EMD-72193

Single-particle
3.3 Å
EMD-72193
3D View Gallery
Deposition: 18/08/2025
Map released: 29/10/2025
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72193

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q3g summary report (pdf.gz) Map-9q3g FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human AGO1 in complex with guide RNA

EMD-72193

Single-particle
3.3 Å
EMD-72193
3D View Gallery
Deposition: 18/08/2025
Map released: 29/10/2025
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Trichoplusia ni
Sample: Complex of human Argonaute1 bound to a non-homogenous guide RNA
Fitted models: 9q3g

Deposition Authors: Savidge A , Adhav V , Shen Z , Fu T, Nakanishi K
Neurodevelopmental disorder-linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3'→5' trimming.
Savidge A , Zhang H , Annasaheb Adhav V, Kehling AC, Sim G, Shen Z , Fu TM , Nakanishi K
(2025) PNAS , 122 , e2524644122 - e2524644122
PUBMED: 41237208
DOI: doi:10.1073/pnas.2524644122
ISSN: 1091-6490
ASTM: PNASA6