EMD-72192

Single-particle
3.3 Å
EMD-72192
3D View Gallery
Deposition: 18/08/2025
Map released: 05/11/2025
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72192

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q3f summary report (pdf.gz) Map-9q3f FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of neurodevelopmental mutant AGO1 F180del in complex with guide RNA

EMD-72192

Single-particle
3.3 Å
EMD-72192
3D View Gallery
Deposition: 18/08/2025
Map released: 05/11/2025
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Trichoplusia ni
Sample: Complex of human Argonaute1 F180Deletion bound to a non-homogenous guide RNA
Fitted models: 9q3f

Deposition Authors: Savidge A , Adhav V , Shen Z , Fu T, Nakanishi K
Neurodevelopmental disorder-linked Argonaute mutations permit delayed RISC formation and unusual shortening of miRNAs by 3'→5' trimming.
Savidge A , Zhang H , Annasaheb Adhav V, Kehling AC, Sim G, Shen Z , Fu TM , Nakanishi K
(2025) PNAS , 122 , e2524644122 - e2524644122
PUBMED: 41237208
DOI: doi:10.1073/pnas.2524644122
ISSN: 1091-6490
ASTM: PNASA6