EMD-72100

Single-particle
2.8 Å
EMD-72100
3D View Gallery
Deposition: 13/08/2025
Map released: 03/06/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72100

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q0n summary report (pdf.gz) Map-9q0n FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of PPAT-NUDT5 complex bound to 6-methylthioinosine-5'-monophosphate (6-meTIMP)

EMD-72100

Single-particle
2.8 Å
EMD-72100
3D View Gallery
Deposition: 13/08/2025
Map released: 03/06/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of PPAT and NUDT5 with 6-methylthioinosine-5'-monophosphate
Fitted models: 9q0n

Deposition Authors: Witus SRW, Yang Z , Rape M
Metabolite glues as a means of purine sensing and chemotherapeutic response.
Witus SR , Kober MM , Roh H , Yang Z , Choueiry F , Ghate AS , Titov DV , Rape M
(2026) Nature , 655 , 1300 - 1308
PUBMED: 42457960
DOI: doi:10.1038/s41586-026-10790-3
ISSN: 1476-4687
ASTM: NATUAS