EMD-71894

Single-particle
3.89 Å
EMD-71894
3D View Gallery
Deposition: 03/08/2025
Map released: 10/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71894

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9pvo summary report (pdf.gz) Map-9pvo FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Novel site 1 interaction of the IR/Ins-AC-S2 complex

EMD-71894

Single-particle
3.89 Å
EMD-71894
3D View Gallery
Deposition: 03/08/2025
Map released: 10/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Half model of the insulin receptor-A isoform complexed with Ins-AC-S2.
Fitted models: 9pvo

Deposition Authors: Vogel A, Blakely A, Hill CP
Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands S961 and Ins-AC-S2.
Vogel A, Blakely A, Dao Y, Lin NP, Chou D, Hill CP
(2026) Nat Commun , 17
PUBMED: 42265100
DOI: doi:10.1038/s41467-026-73851-1
ISSN: 2041-1723