EMD-71743

Single-particle
2.1 Å
EMD-71743
3D View Gallery
Deposition: 18/07/2025
Map released: 20/08/2025
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71743

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9pmw summary report (pdf.gz) Map-9pmw FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of HTTQ23-HAP40 complex bound to macrocycles HHL1, HD4 and HL2

EMD-71743

Single-particle
2.1 Å
EMD-71743
3D View Gallery
Deposition: 18/07/2025
Map released: 20/08/2025
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: HTT Q23 - HAP40 complex with macrocycles HHL1, HD4 and HL2
Fitted models: 9pmw

Deposition Authors: Balakrishnan S , Deme J, Lea SM, Harding RJ
High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.
Fanti R , Wolf E, Ikenoue T , Deme JC , Balakrishnan S , Keith BA, Alteen MG , Chandrasekaran R , Yadav M , Bhajiawala R, Ackloo S, Feng J , Pouladi MA , Edwards AM , Wilson DJ, Lea SM, Suga H , Harding RJ
(2026) PNAS , 123 , e2520462123 - e2520462123
PUBMED: 41838909
DOI: doi:10.1073/pnas.2520462123
ISSN: 1091-6490
ASTM: PNASA6