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EMD-71718
Locally-refined structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905)
EMD-71718
Single-particle2.8 Å
Deposition: 15/07/2025Map released: 20/08/2025
Last modified: 20/08/2025
Sample Organism:
Homo sapiens
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound 4905.
Fitted models: 9pln
Deposition Authors: Srinivasan K
,
Xu X ,
Mailhot O ,
Manglik A ,
Shoichet B
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound 4905.
Fitted models: 9pln
Deposition Authors: Srinivasan K
,
Xu X ,
Mailhot O ,
Manglik A ,
Shoichet B
Toward a Random Background for Ligand Optimization
Xu X ,
Mailhot O ,
Correy G,
Huang XP,
Braz J,
Shi D,
Srinivasan K ,
Holota Y,
Kuziv Y,
Tsoutsouvas C,
Levinzon N,
Doruk YU,
Rachman M,
Diolaiti M,
Stevens M,
Liu F,
Hubner H,
Wang J,
Wu Y,
Ashworth A,
Makriyannis A,
Zhang Y,
Moroz Y,
Gmeiner P,
Abel R,
Manglik A ,
Basbaum A,
Roth B,
Fraser J,
Shoichet B
To Be Published
,
Mailhot O ,
Correy G,
Huang XP,
Braz J,
Shi D,
Srinivasan K ,
Holota Y,
Kuziv Y,
Tsoutsouvas C,
Levinzon N,
Doruk YU,
Rachman M,
Diolaiti M,
Stevens M,
Liu F,
Hubner H,
Wang J,
Wu Y,
Ashworth A,
Makriyannis A,
Zhang Y,
Moroz Y,
Gmeiner P,
Abel R,
Manglik A ,
Basbaum A,
Roth B,
Fraser J,
Shoichet B
To Be Published
Grant Support:
- Defense Advanced Research Projects Agency (DARPA): (United States)