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EMD-71559
Cryo-EM structure of CCR6 bound by PF-07054894 and OXM2
EMD-71559
Single-particle3.35 Å
Deposition: 02/07/2025Map released: 01/10/2025
Last modified: 22/10/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Complex of Human CCR6/PF-07054894/OXM2 with anti-BRIL Fab and anti-BRIL Fab Nanobody
Fitted models: 9pee
Deposition Authors: Wasilko DJ, Wu H
Sample: Complex of Human CCR6/PF-07054894/OXM2 with anti-BRIL Fab and anti-BRIL Fab Nanobody
Fitted models: 9pee
Deposition Authors: Wasilko DJ, Wu H
Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity.
Schnute ME,
Wu H,
Trujillo JI,
Li W,
Wasilko DJ,
Alley J,
Arnold EP,
Bagley SW,
Berstein G,
Blakemore DC,
Bundesmann MW,
Chinigo GM,
Choi C,
Cooke R,
Crouse K,
Dermenci A,
Dickinson T,
Flick A,
Frisbie RK,
Garcia-Irizarry C,
Gerstenberger BS,
Hepworth D,
Kaila N,
Kung DW,
Lamb D,
Lavergne SY,
Limburg DC,
Liu S,
Lombardo VM,
Mondal PK,
Mousseau JJ,
Narayanan A,
Niljianskul N,
Nuhant P,
Pan S,
Primiano MJ,
Rappas M,
Schmitt DC,
Steyn SJ,
Unwalla R,
Vasa D,
Vazquez ML,
Vincent F,
Yang X,
Thorarensen A
(2025) J Med Chem , 68 , 20689 - 20716
(2025) J Med Chem , 68 , 20689 - 20716
Grant Support: