EMD-71559
Cryo-EM structure of CCR6 bound by PF-07054894 and OXM2
EMD-71559
Single-particle3.35 Å
Deposition: 02/07/2025Map released: 01/10/2025
Last modified: 22/10/2025
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Complex of Human CCR6/PF-07054894/OXM2 with anti-BRIL Fab and anti-BRIL Fab Nanobody
Fitted models: 9pee
Deposition Authors: Wasilko DJ, Wu H
Sample: Complex of Human CCR6/PF-07054894/OXM2 with anti-BRIL Fab and anti-BRIL Fab Nanobody
Fitted models: 9pee
Deposition Authors: Wasilko DJ, Wu H
Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity.
Schnute ME ,
Wu H ,
Trujillo JI ,
Li W,
Wasilko DJ,
Alley J,
Arnold EP,
Bagley SW ,
Berstein G,
Blakemore DC,
Bundesmann MW,
Chinigo GM ,
Choi C ,
Cooke R,
Crouse K,
Dermenci A,
Dickinson T,
Flick A ,
Frisbie RK,
Garcia-Irizarry C,
Gerstenberger BS ,
Hepworth D,
Kaila N,
Kung DW ,
Lamb D,
Lavergne SY,
Limburg DC,
Liu S,
Lombardo VM,
Mondal PK,
Mousseau JJ ,
Narayanan A ,
Niljianskul N,
Nuhant P,
Pan S,
Primiano MJ ,
Rappas M,
Schmitt DC,
Steyn SJ,
Unwalla R,
Vasa D,
Vazquez ML,
Vincent F,
Yang X,
Thorarensen A
(2025) J Med Chem , 68 , 20689 - 20716
,
Wu H ,
Trujillo JI ,
Li W,
Wasilko DJ,
Alley J,
Arnold EP,
Bagley SW ,
Berstein G,
Blakemore DC,
Bundesmann MW,
Chinigo GM ,
Choi C ,
Cooke R,
Crouse K,
Dermenci A,
Dickinson T,
Flick A ,
Frisbie RK,
Garcia-Irizarry C,
Gerstenberger BS ,
Hepworth D,
Kaila N,
Kung DW ,
Lamb D,
Lavergne SY,
Limburg DC,
Liu S,
Lombardo VM,
Mondal PK,
Mousseau JJ ,
Narayanan A ,
Niljianskul N,
Nuhant P,
Pan S,
Primiano MJ ,
Rappas M,
Schmitt DC,
Steyn SJ,
Unwalla R,
Vasa D,
Vazquez ML,
Vincent F,
Yang X,
Thorarensen A
(2025) J Med Chem , 68 , 20689 - 20716
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