EMD-71555
Cryo-EM structure of full-length human TRPV1 in complex with analgesic MSP20
EMD-71555
Single-particle2.6 Å
Deposition: 01/07/2025Map released: 22/07/2026
Last modified: 26/08/2026
Sample Organism:
Homo sapiens
Sample: full-length human TRPV1 in complex with MSP20
Fitted models: 9pea
Deposition Authors: Neuberger A
,
Talyzina IA ,
Romeo I,
Aiello F,
Maramai S ,
Alcaro S ,
Artese A ,
Brizzi A ,
Sobolevsky AI
Sample: full-length human TRPV1 in complex with MSP20
Fitted models: 9pea
Deposition Authors: Neuberger A
,
Talyzina IA ,
Romeo I,
Aiello F,
Maramai S ,
Alcaro S ,
Artese A ,
Brizzi A ,
Sobolevsky AI
Design, synthesis and structural mechanism of action of TRPV1 agonist MSP20 with long-lasting analgesic effect.
Neuberger A ,
Romeo I,
Aiello F,
Alekseev A,
Maramai S ,
Pessina F,
Vagaggini C,
Poggialini F,
Dreassi E,
Frosini M,
Schiano Moriello A,
De Petrocellis L,
Morace AM,
Belardo C,
Perrone M,
Bonsale R,
Luongo L ,
Maione S,
Talyzina IA ,
Alcaro S ,
Artese A ,
Brizzi A ,
Sobolevsky AI
(2026) Nat Commun , 17
,
Romeo I,
Aiello F,
Alekseev A,
Maramai S ,
Pessina F,
Vagaggini C,
Poggialini F,
Dreassi E,
Frosini M,
Schiano Moriello A,
De Petrocellis L,
Morace AM,
Belardo C,
Perrone M,
Bonsale R,
Luongo L ,
Maione S,
Talyzina IA ,
Alcaro S ,
Artese A ,
Brizzi A ,
Sobolevsky AI
(2026) Nat Commun , 17
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01 CA206573 (United States)
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): R01 AR078814 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS107253 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R37 NS083660 (United States)