EMD-71254

Single-particle
3.0 Å
EMD-71254
3D View Gallery
Deposition: 14/06/2025
Map released: 07/01/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71254

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9p3t summary report (pdf.gz) Map-9p3t FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Zebrafish TRPM5 with 5mM calcium and 0.5mM TPPO

EMD-71254

Single-particle
3.0 Å
EMD-71254
3D View Gallery
Deposition: 14/06/2025
Map released: 07/01/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Danio rerio
Sample: zebrafish TRPM5 D797A mutant in GDN detergent with 5mM calcium
Fitted models: 9p3t

Deposition Authors: Ruan Z , Du J , Lu W
A single allosteric site merges activation, modulation and inhibition in TRPM5.
Ruan Z , Lee J, Li Y, Orozco IJ, Du J , Lu W
(2026) Nat Chem Biol , 22 , 402 - 410
PUBMED: 41491833
DOI: doi:10.1038/s41589-025-02097-7
ISSN: 1552-4469