EMD-70613
Cryo-EM structure of rhesus antibody V033-Int1 in complex with HIV Env trimer Q23.17 MD39
EMD-70613
Single-particle3.6 Å
Deposition: 13/05/2025Map released: 05/11/2025
Last modified: 25/02/2026
Sample Organism:
Macaca mulatta,
Homo sapiens
Sample: V033-Int1 Fab in complex with Q23.17 MD39 envelope trimer
Fitted models: 9omg
Deposition Authors: Roark RS
,
Shapiro L ,
Kwong PD
Sample: V033-Int1 Fab in complex with Q23.17 MD39 envelope trimer
Fitted models: 9omg
Deposition Authors: Roark RS
,
Shapiro L ,
Kwong PD
Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.
Habib R ,
Roark RS ,
Li H ,
Connell AJ ,
Hogarty MP ,
Wagh K ,
Wang S ,
Marchitto L ,
Skelly AN ,
Carey JW ,
Sowers KJ ,
Ayyanathan K ,
Plante SJ ,
Bibollet-Ruche F ,
Park Y ,
Agostino CJ ,
Singh A ,
Martella CL ,
Lewis E ,
Rando JM ,
Chohan N,
Lora J,
Ding W,
Campion MS,
Zhao C,
Liu W ,
Li Y ,
Li X ,
Liang B,
Chowdhury RR ,
Amereh K,
Van Itallie E ,
Sheng Z ,
Ghosh AR ,
Bar KJ ,
Williams WB ,
Wiehe K ,
Saunders KO ,
Edwards RJ ,
Cain DW ,
Lewis MG ,
Batista FD ,
Burton DR ,
Andrabi R ,
Kulp DW,
Haynes BF ,
Korber B ,
Shapiro L ,
Kwong PD ,
Hahn BH,
Shaw GM
(2026) Sci Immunol , 11 , eadz3933 - eadz3933
,
Roark RS ,
Li H ,
Connell AJ ,
Hogarty MP ,
Wagh K ,
Wang S ,
Marchitto L ,
Skelly AN ,
Carey JW ,
Sowers KJ ,
Ayyanathan K ,
Plante SJ ,
Bibollet-Ruche F ,
Park Y ,
Agostino CJ ,
Singh A ,
Martella CL ,
Lewis E ,
Rando JM ,
Chohan N,
Lora J,
Ding W,
Campion MS,
Zhao C,
Liu W ,
Li Y ,
Li X ,
Liang B,
Chowdhury RR ,
Amereh K,
Van Itallie E ,
Sheng Z ,
Ghosh AR ,
Bar KJ ,
Williams WB ,
Wiehe K ,
Saunders KO ,
Edwards RJ ,
Cain DW ,
Lewis MG ,
Batista FD ,
Burton DR ,
Andrabi R ,
Kulp DW,
Haynes BF ,
Korber B ,
Shapiro L ,
Kwong PD ,
Hahn BH,
Shaw GM
(2026) Sci Immunol , 11 , eadz3933 - eadz3933
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