EMD-70501

Single-particle
2.46 Å
EMD-70501
3D View Gallery
Deposition: 05/05/2025
Map released: 27/05/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70501

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ohn summary report (pdf.gz) Map-9ohn FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human p97/VCP bound to inhibitor GND-135

EMD-70501

Single-particle
2.46 Å
EMD-70501
3D View Gallery
Deposition: 05/05/2025
Map released: 27/05/2026
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human p97/VCP
Fitted models: 9ohn

Deposition Authors: Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Dos Santos N, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk A, Cholak S, Cameron D, Subramaniam S
Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor.
Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Santos ND, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk AM, Cholak S, Merk A, Cameron DR, Subramaniam S
(2026) IUCrJ , 13 , 364 - 372
PUBMED: 42329166
DOI: doi:10.1107/S2052252526004604
ISSN: 2052-2525
Grant Support: