EMD-70459

Single-particle
3.37 Å
EMD-70459
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Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70459
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9oga summary report (pdf.gz) Map and 9oga FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human full-length XPO1 conjugated with selinexor

EMD-70459

Single-particle
3.37 Å
EMD-70459
3D View Gallery
Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human wildtype full-length exportin-1 (XPO1) covalently bound to selinexor
Fitted models: 9oga

Deposition Authors: Wing CE, Fung HYJ, Chook YM
SINE compounds activate exportin-1 degradation via an allosteric mechanism.
Wing CE, Fung HYJ, Kwanten B, Cagatay T, Niesman AB, Jacquemyn M, Gharghabi M, Permentier B, Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM
(2025) bioRxiv
PUBMED: 39416201
DOI: doi:10.1101/2024.10.07.617049
ISSN: 2692-8205