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EMD-70021
BG505-DS SOSIP in complex with 007 bNAb Fabs - Class 3 (3 Fabs bound)
EMD-70021
Single-particle3.4 Å
Deposition: 04/04/2025Map released: 01/10/2025
Last modified: 01/10/2025
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1
Sample: HIV-1 BG505-DS SOSIP trimer bound by three 007 bNAb Fabs
Fitted models: 9o2t
Deposition Authors: DeLaitsch AT, Bjorkman PJ
Sample: HIV-1 BG505-DS SOSIP trimer bound by three 007 bNAb Fabs
Fitted models: 9o2t
Deposition Authors: DeLaitsch AT, Bjorkman PJ
Identification of a broad and potent V3 glycan site bNAb targeting an N332 gp120 glycan-independent epitope.
Gieselmann L,
DeLaitsch AT,
Rohde M,
Radford C,
Worczinski J,
Momot A,
Ahmadov E,
Burger JA,
Havenar-Daughton C,
Deshpande S,
Giovannoni F,
Corti D,
Kreer C 
,
Ercanoglu MS,
Schommers P,
Georgiev IS,
West AP,
Knufer J,
Stumpf R,
Kroidl A,
Geldmacher C,
Maganga L,
William W,
Ntinginya NE,
Hoelscher M,
Yang Z,
Wei Q,
Renfrow M,
Green TJ,
Novak J,
van Gils MJ ,
Gristick HB ,
Gruell H ,
Bloom JD ,
Seaman MS,
Bjorkman PJ,
Klein F
(2025) bioRxiv
,
Ercanoglu MS,
Schommers P,
Georgiev IS,
West AP,
Knufer J,
Stumpf R,
Kroidl A,
Geldmacher C,
Maganga L,
William W,
Ntinginya NE,
Hoelscher M,
Yang Z,
Wei Q,
Renfrow M,
Green TJ,
Novak J,
van Gils MJ ,
Gristick HB ,
Gruell H ,
Bloom JD ,
Seaman MS,
Bjorkman PJ,
Klein F
(2025) bioRxiv
Grant Support:
- Bill & Melinda Gates Foundation: INV-002143 (United States)