EMD-68747
Structure of CXCR4 in complex with a de-novo designed mini-protein antagonist
EMD-68747
Single-particle3.28 Å
Deposition: 26/01/2026Map released: 22/04/2026
Last modified: 03/06/2026
Sample Organism:
Homo sapiens,
synthetic construct
Sample: C-X-C chemokine receptor type 4 in complex with dCX001
Fitted models: 22xc
Deposition Authors: Banerjee R, Ganguly M, Banerjee N, Tiwari D, Muratspahic E, Baker D, Shukla AK
Sample: C-X-C chemokine receptor type 4 in complex with dCX001
Fitted models: 22xc
Deposition Authors: Banerjee R, Ganguly M, Banerjee N, Tiwari D, Muratspahic E, Baker D, Shukla AK
De novo design of miniproteins targeting GPCRs.
Muratspahic E,
Feldman D,
Kim DE,
Qu X,
Bratovianu AM,
Rivera-Sanchez P,
Voss JH,
Hertz EPT,
Jeppesen M,
Dimitri F,
Sakamoto K,
Nallathambi A,
Peceli P,
Cao J,
Cary BP,
Belousoff MJ,
Keov P,
Trinh PNH,
Chen Q,
Ren Y,
Fine J,
Mishra S,
Dalal A,
Sinha S,
Banerjee R,
Ganguly M,
Karuppusamy KV,
Sappington I,
Schlichthaerle T,
Zhang JZ,
Pillai A,
Coventry B,
Mihaljevic L,
Bauer M,
Torres SV,
Motmaen A,
Lee GR,
Tran L,
Wang X,
Goreshnik I,
Vafeados DK,
Svendsen JE,
Hosseinzadeh P,
Lindegaard N,
Brandt M,
Waltenspuhl Y,
Deibler K,
Deweid L,
Bennett A,
Schoppe J,
Dong T,
Yan X,
Oostdyk L,
Cao W,
Anantharaman L,
Weisser JJ,
Bastlund JF,
Bundgaard C,
Asuni AA,
English JG,
Stewart L,
Halloran L,
Spangler JB,
Lieber A,
Shukla AK,
Sexton PM,
Roth BL,
Krumm BE,
Wootten D,
Tate CG,
Norn C,
Baker D
(2026) Nature
(2026) Nature
Grant Support:
- Science and Engineering Research Board (SERB): IPA/2020/000405 (India)
- Wellcome Trust: IA/S/20/1/504916 (United Kingdom)
- Science and Engineering Research Board (SERB): CRG/2022/002646 (India)
