EMD-68650
5HT2AR-miniGq heterotrimer in complex with a novel agonist IHCH-8152
EMD-68650
Single-particle3.2 Å
Deposition: 22/01/2026Map released: 21/10/2026
Last modified: 04/11/2026
Sample Organism:
Homo sapiens
Sample: 5-HT2A receptor bound to IHCH-8152 in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Fitted models: 22ta
Deposition Authors: Tang L, Cao M, Li H, Meng B
,
Liu Z,
Cheng J ,
Wang S
Sample: 5-HT2A receptor bound to IHCH-8152 in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Fitted models: 22ta
Deposition Authors: Tang L, Cao M, Li H, Meng B
,
Liu Z,
Cheng J ,
Wang S
Sustained antidepressant-like effects of psychedelics through 5-HT 2A R-beta-arrestin signaling.
He L ,
Tang L,
Cao D,
Duan W,
Yu J ,
Zhang P ,
Li H,
Wang Y,
Meng B ,
Wang H,
Zhou Y,
Li W,
Li X,
Liu Z,
Zhang L,
Cheng J ,
Wang S
(2026) Nat Neurosci
,
Tang L,
Cao D,
Duan W,
Yu J ,
Zhang P ,
Li H,
Wang Y,
Meng B ,
Wang H,
Zhou Y,
Li W,
Li X,
Liu Z,
Zhang L,
Cheng J ,
Wang S
(2026) Nat Neurosci
Grant Support:
- National Natural Science Foundation of China (NSFC): 82225045 (China)
- Other government: Ministry of Science and Technology of China (2020YFA0509600 to S.W.)
- National Natural Science Foundation of China (NSFC): 22177074 (China)
- National Natural Science Foundation of China (NSFC): 22377077 (China)
- Other government: Program of Shanghai Academic/Technology Research Leader (22XD1421900 to J.C.)
- Other government: Shanghai Municipal Government and ShanghaiTech University (to J.C.)