EMD-67119

Single-particle
3.91 Å
EMD-67119
3D View Gallery
Deposition: 18/11/2025
Map released: 04/02/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-67119

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9xqn summary report (pdf.gz) Map-9xqn FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of apo form of GPR75-bRIL-Fab complex

EMD-67119

Single-particle
3.91 Å
EMD-67119
3D View Gallery
Deposition: 18/11/2025
Map released: 04/02/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of apo form of GPR75-bRIL-Fab complex
Fitted models: 9xqn

Deposition Authors: Wu C, Yuan Q
Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target.
Zhu ZN, You CZ, Yuan QN, Xu JY, Gu ZY, Huang Z, Liu M, Shan B, Wang JJ, Hu W, Wang K, Yin WC, Xu YW, Xu HE, Wu CR
(2026) Acta Pharmacol.Sin. , 47 , 1351 - 1360
PUBMED: 41545757
DOI: doi:10.1038/s41401-025-01720-6
ISSN: 1745-7254
Grant Support: