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EMD-66460
Cryo-EM Structure of human complement C1s CUB domain in complex with RAY121
EMD-66460
Single-particle2.6 Å
Deposition: 02/10/2025Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Homo sapiens
Sample: human complement C1s CUB domain in complex with RAY121
Fitted models: 9x1h
Deposition Authors: Kawauchi H, Adrian H, Gupta G, Koga H, Fujii T, Fukumura T, Ishino S, Irie M, Torizawa T
Sample: human complement C1s CUB domain in complex with RAY121
Fitted models: 9x1h
Deposition Authors: Kawauchi H, Adrian H, Gupta G, Koga H, Fujii T, Fukumura T, Ishino S, Irie M, Torizawa T
Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function.
Ho AWS 
,
Fukuzawa T,
Koga H,
Ohmine K,
Kawauchi H,
Muraoka M ,
Ikuta Y,
Gupta G,
Okuda M,
Onami I,
Ayabe M,
Takeiri A,
Konishi H,
Sugawara Y,
Usami S,
Ito E,
Shibahara N,
Ozeki K,
Wada Y,
Hirako A,
Takahashi N,
Sampei Z,
Haraya K,
Murao N,
Fujii T,
Torizawa T,
Shimada H,
Igawa T
(2025) Ebiomedicine , 122 , 106009 - 106009
,
Fukuzawa T,
Koga H,
Ohmine K,
Kawauchi H,
Muraoka M ,
Ikuta Y,
Gupta G,
Okuda M,
Onami I,
Ayabe M,
Takeiri A,
Konishi H,
Sugawara Y,
Usami S,
Ito E,
Shibahara N,
Ozeki K,
Wada Y,
Hirako A,
Takahashi N,
Sampei Z,
Haraya K,
Murao N,
Fujii T,
Torizawa T,
Shimada H,
Igawa T
(2025) Ebiomedicine , 122 , 106009 - 106009
Grant Support: