EMD-65110

Single-particle
2.47 Å
EMD-65110
3D View Gallery
Deposition: 19/06/2025
Map released: 12/11/2025
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-65110

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9vje summary report (pdf.gz) Map-9vje FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of 5-HT1AR-GoA in complex with buspirone

EMD-65110

Single-particle
2.47 Å
EMD-65110
3D View Gallery
Deposition: 19/06/2025
Map released: 12/11/2025
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Cryo-EM structure of 5-HT1AR-GoA in complex with buspirone
Fitted models: 9vje

Deposition Authors: Wang C, Cao C
Pathway-selective 5-HT 1A R agonist as a rapid antidepressant strategy.
Wang C, Zhang N, Shao Y, Li T, Zhang M, Gao M, Liang Y, Wang Y, Xue T, Shi Y, Chen H , Cao C
(2025) Cell , 188 , 7222 - 7237.e24
PUBMED: 41232528
DOI: doi:10.1016/j.cell.2025.10.022
ISSN: 1097-4172