EMD-64829

Single-particle
2.63 Å
EMD-64829
3D View Gallery
Deposition: 29/05/2025
Map released: 06/05/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-64829

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9v81 summary report (pdf.gz) Map-9v81 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

cryoEM structure of HEP-50768-bound MRGPRX4-Gq complex

EMD-64829

Single-particle
2.63 Å
EMD-64829
3D View Gallery
Deposition: 29/05/2025
Map released: 06/05/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Structure of an antagonist-bound MRGPRX4-Gq complex
Fitted models: 9v81

Deposition Authors: Wang C, Zhang M, Cao C
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment.
Yang J, Shen R, Wang C, Zhu W, Ke H, Fan J, Zhang M, Liu Y, Li S, Li G, Wang X, Li Y, Cao C, Lei X
(2026) Nat Chem Biol
PUBMED: 41957282
DOI: doi:10.1038/s41589-026-02195-0
ISSN: 1552-4469