EMD-64791

Single-particle
2.85 Å
EMD-64791
3D View Gallery
Deposition: 26/05/2025
Map released: 08/04/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-64791

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9v5p summary report (pdf.gz) Map-9v5p FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of human DNMT1 (aa 698-1616) in complex with hemimethylated dsDNA and inhibitor DMT207

EMD-64791

Single-particle
2.85 Å
EMD-64791
3D View Gallery
Deposition: 26/05/2025
Map released: 08/04/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human DNMT1 in complex with hemimethylated dsDNA and inhibitor DMT207
Fitted models: 9v5p

Deposition Authors: Li Z
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating beta-Thalassemia.
Shen Y, Wei J, Tang S, Wu D, Zong L, Ma S, Xiong Q, Gong R, Xu S, Peng C, Feng Q, Liu S, Liu Q, Ye Y, Zhao Q, Luo C, Huang P, Li Z, Kong X, Lan X
(2026) Adv Sci , 13 , e13469 - e13469
PUBMED: 41347631
DOI: doi:10.1002/advs.202513469
ISSN: 2198-3844