EMD-63105

Single-particle
3.0 Å
EMD-63105
3D View Gallery
Deposition: 13/01/2025
Map released: 13/08/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-63105

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9lht summary report (pdf.gz) Map-9lht FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of inhibitor E3 bound human urea transporter A2.

EMD-63105

Single-particle
3.0 Å
EMD-63105
3D View Gallery
Deposition: 13/01/2025
Map released: 13/08/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Spodoptera aff. frugiperda 1 BOLD-2017, Homo sapiens
Sample: Homotrimer complex of human urea transporter
Fitted models: 9lht

Deposition Authors: Huang S, Liu L , Sun J
Structural characterization of the urea transporter bound to the orally bioavailable inhibitor E3.
Huang SM, Cai BY, Liu L , Yang LJ, Li Z, Zhang C, Xiong MY, Zhang H, Li YR, Huang ZZ, Sun Y, Yang BX, Sun JP
(2025) Acta Pharmacol.Sin. , 46 , 2989 - 2997
PUBMED: 40523902
DOI: doi:10.1038/s41401-025-01595-7
ISSN: 1745-7254