EMD-62784

Single-particle
3.09 Å
EMD-62784
3D View Gallery
Deposition: 18/12/2024
Map released: 24/12/2025
Last modified: 18/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-62784

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9l3f summary report (pdf.gz) Map-9l3f FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity

EMD-62784

Single-particle
3.09 Å
EMD-62784
3D View Gallery
Deposition: 18/12/2024
Map released: 24/12/2025
Last modified: 18/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Short transient receptor potential channel 5
Fitted models: 9l3f

Deposition Authors: Che T, Zhang J, Xiong B, Cheng XY
Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity.
Che T, Chen Y, Cheng X, Hu H, Wu X, Zhang Y, Yang X, Liu Y, Liu H, Nan W, Wan S, Yang M, Zeng B, Li J, Zhang J, Xiong B
(2026) Acta Pharm Sin B , 16 , 371 - 386
PUBMED: 41584354
DOI: doi:10.1016/j.apsb.2025.10.028
ISSN: 2211-3835