EMD-60981

Single-particle
3.1 Å
EMD-60981
3D View Gallery
Deposition: 29/07/2024
Map released: 19/03/2025
Last modified: 13/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60981

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ixy summary report (pdf.gz) Map-9ixy FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human KCNQ2-CaM-Ebio2 Complex in the Presence of PIP2

EMD-60981

Single-particle
3.1 Å
EMD-60981
3D View Gallery
Deposition: 29/07/2024
Map released: 19/03/2025
Last modified: 13/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: KCNQ2-Ebio2
Fitted models: 9ixy

Deposition Authors: Yang Z, Guo J
Small molecule inhibits KCNQ channels with a non-blocking mechanism.
Li J, Yang Z, Zhang S, Ye Y, He J, Zhang Y, Han H, Kong W, Liu J, Min Y, Shen J, Mei L, Chen Z, Hou P, Guo J , Zhang Q , Yang H
(2025) Nat Chem Biol , 21 , 1100 - 1109
PUBMED: 39814994
DOI: doi:10.1038/s41589-024-01834-8
ISSN: 1552-4469