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EMD-60767

Single-particle
3.85 Å
EMD-60767
3D View Gallery
Deposition: 10/07/2024
Map released: 28/05/2025
Last modified: 06/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60767
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ipa summary report (pdf.gz) Map and 9ipa FULL report (pdf.gz)
EMICSS annotations (xml)

HL-type bispecific diabody Ex3 composed of 528 and OKT3 Fvs in ternary complex with sEGFR and CD3gamma-epsilon (open conformation)

EMD-60767

Single-particle
3.85 Å
EMD-60767
3D View Gallery
Deposition: 10/07/2024
Map released: 28/05/2025
Last modified: 06/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: HL-type bispecific antibody Ex3 composed of 528 and OKT3 Fvs in ternary complex with sEGFR and CD3gamma-epsilon
Fitted models: 9ipa

Deposition Authors: Sato K, Uehara S, Tsugita A, Matsui T , Asano R, Makabe K, Yokoyama T, Tanaka Y
Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement.
Sato K, Uehara S, Tsugita A, Ishii M, Ishiyama S, Maejima A, Nakahara I, Nazuka M, Matsui T , Christos G, Yokoyama T, Kumagai I, Makabe K, Asano R, Tanaka Y
(2025) Cell Rep , 44 , 115965 - 115965
PUBMED: 40664209
DOI: doi:10.1016/j.celrep.2025.115965
ISSN: 2211-1247