Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-60339
Cryo-EM map of respirasome closed state 1 in the absence of biguanide (SC-ApoC), complex I peripheral arm focused
EMD-60339
Single-particle2.84 Å
Deposition: 30/05/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Sus scrofa
Sample: Respirasome close state 1 in absence of biguanide
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome close state 1 in absence of biguanide
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z,
Teng F ,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
Grant Support: