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EMD-60310
Cryo-EM map of respirasome closed state 1 bound by metformin (SC-MetC1), complex I distal membrane arm focused
EMD-60310
Single-particle2.75 Å
Deposition: 28/05/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Sus scrofa
Sample: Respirasome close state 1 in presence of metformin
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome close state 1 in presence of metformin
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z,
Teng F ,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
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