EMD-60301
Cryo-EM map of respirasome open state 1 in presence of metformin (SC-MetO1), complex I peripheral arm focused
EMD-60301
Single-particle2.97 Å
Deposition: 28/05/2024Map released: 17/12/2025
Last modified: 08/07/2026
Sample Organism:
Sus scrofa
Sample: Respirasome open state 1 in presence of metformin
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome open state 1 in presence of metformin
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
,
Teng F ,
Yang Y ,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
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