EMD-59344

Single-particle
2.2 Å
EMD-59344
3D View Gallery
Deposition: 09/08/2026
Map released: 26/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-59344

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-33ci summary report (pdf.gz) Map-33ci FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-58

EMD-59344

Single-particle
2.2 Å
EMD-59344
3D View Gallery
Deposition: 09/08/2026
Map released: 26/08/2026
Last modified: 26/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: MAGE-A4 (230-239)-bound HLA-A*02:01 in complex with Fab VR-58
Fitted models: 33ci

Deposition Authors: Schuster S, Weng T-H, Reinhart C, Michel H, Birkenfeld J

Systematic De-Risking of TCR-Mimic Therapeutics Through Proteome-Wide Off-Target Landscaping and a Generalizable Design Rule Framework
Schuster S, Hartl FA, Stehle J, Beier F, Al-Hasani H, Reinhart C, Weng T-H, Kraemer S, Hamde P, Herz T, Oesterlin S, Schmidt M, Gross T, Stehl L, Kilb N, Juenemann G, Heiss K, Sinclair A, Schoettgen J, Meyer P, Atay B, Zaghla BKQ, Link S, Goll J, Leoni B, Steinmann B, Selinger O, Welsch S, Roth G, Michel H, Klatt M, Birkenfeld J
To Be Published
Grant Support: