EMD-57180

Single-particle
5.9 Å
EMD-57180
3D View Gallery
Deposition: 11/03/2026
Map released: 06/05/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-57180

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-29hi summary report (pdf.gz) Map-29hi FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

EMD-57180

Single-particle
5.9 Å
EMD-57180
3D View Gallery
Deposition: 11/03/2026
Map released: 06/05/2026
Last modified: 08/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: SCF FBXO22, NSD2, UNC10088
Fitted models: 29hi

Deposition Authors: Amann SJ, Robertson KC, Grishkovskaya I, Liu T, James LI, Brown NB, Haselbach D
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.
Robertson KC, Amann SJ, Liu T, Funk AV, Wang X, Grishkovskaya I, Mehmood A, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL, Miao Y, Emanuele MJ, Haselbach D, James LI, Brown NG
(2026) Nat Commun , 17
PUBMED: 42026065
DOI: doi:10.1038/s41467-026-72235-9
ISSN: 2041-1723