EMD-56480
Medin fibril generated from the heterotypic interaction of Abeta40 and Medin.
EMD-56480
Helical reconstruction2.7 Å
Deposition: 26/01/2026Map released: 08/04/2026
Last modified: 08/04/2026
Sample Organism:
Homo sapiens
Sample: In vitro assembled Medin, resulting from the co-aggregation of recombinantly purified Amyloid Beta 40 peptide with synthetically produced Medin.
Fitted models: 9u02
Deposition Authors: Pradhan B
,
Kumar ST ,
Wagner J ,
Gallardo R,
Zorzini V ,
Orlando G ,
Vleeschouwer MD ,
Madine J ,
Louros N ,
Neher J ,
Schymkowitz J ,
Rousseau F
Sample: In vitro assembled Medin, resulting from the co-aggregation of recombinantly purified Amyloid Beta 40 peptide with synthetically produced Medin.
Fitted models: 9u02
Deposition Authors: Pradhan B
,
Kumar ST ,
Wagner J ,
Gallardo R,
Zorzini V ,
Orlando G ,
Vleeschouwer MD ,
Madine J ,
Louros N ,
Neher J ,
Schymkowitz J ,
Rousseau F
Medin drives Abeta40 to adopt Abeta42-like fibril polymorphs in vitro
Pradhan B ,
Kumar ST ,
Wagner J ,
Gallardo R,
Zorzini V ,
Orlando G ,
Vleeschouwer MD ,
Madine J ,
Louros N ,
Neher J ,
Schymkowitz J ,
Rousseau F
To Be Published
,
Kumar ST ,
Wagner J ,
Gallardo R,
Zorzini V ,
Orlando G ,
Vleeschouwer MD ,
Madine J ,
Louros N ,
Neher J ,
Schymkowitz J ,
Rousseau F
To Be Published
Grant Support:
- Research Foundation - Flanders (FWO): G0C3522N (Belgium)
- Research Foundation - Flanders (FWO): 12AWB24N (Belgium)
- National Institutes of Health/National Institute on Aging (NIH/NIA): R01AG079234 (United States)