EMD-55685

Single-particle
3.6 Å
EMD-55685
3D View Gallery
Deposition: 12/11/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55685

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9t8d summary report (pdf.gz) Map-9t8d FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of EA-RK-110-bound D3 dopamine receptor

EMD-55685

Single-particle
3.6 Å
EMD-55685
3D View Gallery
Deposition: 12/11/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct, Homo sapiens
Sample: GPCR-Go protein complex
Fitted models: 9t8d

Deposition Authors: Yardeni EH, Kiss DJ, Shavit K, Keseru GM, Shalev-Benami M
The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology
Hadas Yardeni E, Kiss DJ, Sanchez J, Shavit K, Szepesi Kovacs D, Egyed A, Vogt CD, Gaitonde SA, Glenn J, Canals M, Bouvier M, Newman AH, Lane JR, Keseru GM, Shalev-Benami M
(2026) Sci Adv , 12
DOI: doi:10.1126/sciadv.aef7411
ISSN: 2375-2548
Grant Support: