EMD-55684

Single-particle
2.9 Å
EMD-55684
3D View Gallery
Deposition: 12/11/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55684

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9t8c summary report (pdf.gz) Map-9t8c FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go

EMD-55684

Single-particle
2.9 Å
EMD-55684
3D View Gallery
Deposition: 12/11/2025
Map released: 16/09/2026
Last modified: 16/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: D3R-Go protein complex
Fitted models: 9t8c

Deposition Authors: Yardeni EH, Kiss DJ, Keseru GM, Shalev-Benami M
The structure of the dopamine D 3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.
Hadas Yardeni E, Kiss DJ, Sanchez J, Shavit K, Szepesi Kovacs D, Egyed A, Vogt CD, Gaitonde SA, Glenn J, Canals M, Bouvier M, Newman AH, Lane JR, Keseru GM, Shalev-Benami M
(2026) Sci Adv , 12 , eaef7411 - eaef7411
PUBMED: 42664351
DOI: doi:10.1126/sciadv.aef7411
ISSN: 2375-2548
Grant Support: