EMD-55683

Single-particle
2.74 Å
EMD-55683
3D View Gallery
Deposition: 12/11/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55683

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9t88 summary report (pdf.gz) Map-9t88 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo-EM structure of ESG-2-37-bound D3 dopamine receptor with mini-Go

EMD-55683

Single-particle
2.74 Å
EMD-55683
3D View Gallery
Deposition: 12/11/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: GPCR-Go protein complex
Fitted models: 9t88

Deposition Authors: Yardeni EH, Kiss DJ, Keseru GM, Shalev-Benami M
The structure of the dopamine D3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology
Hadas Yardeni E, Kiss DJ, Sanchez J, Shavit K, Szepesi Kovacs D, Egyed A, Vogt CD, Gaitonde SA, Glenn J, Canals M, Bouvier M, Newman AH, Lane JR, Keseru GM, Shalev-Benami M
(2026) Sci Adv , 12
DOI: doi:10.1126/sciadv.aef7411
ISSN: 2375-2548
Grant Support: