EMD-55650

Single-particle
2.85 Å
EMD-55650
3D View Gallery
Deposition: 11/11/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55650

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9t7p summary report (pdf.gz) Map-9t7p FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of ESG-2-36-bound D3 dopamine receptor with mini-Go

EMD-55650

Single-particle
2.85 Å
EMD-55650
3D View Gallery
Deposition: 11/11/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: GPCR-Go protein complex
Fitted models: 9t7p

Deposition Authors: Yardeni EH, Kiss DJ , Keseru GM , Shalev-Benami M
The structure of the dopamine D 3 receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.
Hadas Yardeni E , Kiss DJ , Sanchez J , Shavit K , Szepesi Kovacs D, Egyed A , Vogt CD, Gaitonde SA, Glenn J , Canals M , Bouvier M , Newman AH, Lane JR , Keseru GM , Shalev-Benami M
(2026) Sci Adv , 12 , eaef7411 - eaef7411
PUBMED: 42664351
DOI: doi:10.1126/sciadv.aef7411
ISSN: 2375-2548
Grant Support: