EMD-55480

Single-particle
6.9 Å
EMD-55480
3D View Gallery
Deposition: 24/10/2025
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55480
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9t32 summary report (pdf.gz) Map and 9t32 FULL report (pdf.gz)
EMICSS annotations (xml)

The Cullin 2 RING VHL E3 ligase dimerised by the homoPROTAC CM11

EMD-55480

Single-particle
6.9 Å
EMD-55480
3D View Gallery
Deposition: 24/10/2025
Map released: 03/12/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: The ternary complex of the heteropentameric CRL2VHL (VHL-ElonginC-ElonginC-Cul2-Rbx1) dimerized by the homoPROTAC CM11
Fitted models: 9t32

Deposition Authors: Crowe C, Ciulli A
Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes
Crowe C, Salerno A, Sathe G, Marsh G, Maple H, Ciulli A
(2025) bioRxiv
DOI: doi:10.1101/2025.11.18.689129
ISSN: 2692-8205