EMD-54549

Single-particle
3.3 Å
EMD-54549
3D View Gallery
Deposition: 25/07/2025
Map released: 20/05/2026
Last modified: 20/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54549
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9s3r summary report (pdf.gz) Map and 9s3r FULL report (pdf.gz)
EMICSS annotations (xml)

Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB

EMD-54549

Single-particle
3.3 Å
EMD-54549
3D View Gallery
Deposition: 25/07/2025
Map released: 20/05/2026
Last modified: 20/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
Fitted models: 9s3r

Deposition Authors: Spiteri VA, Nakasone MA, Casement R, Iso K, Cowan AD, Ciulli A

Dual E3 ligase recruitment by monovalent degraders enables redundant and tunable degradation of SMARCA2/4.
Spiteri VA, Segal D, Correa-Saez A, Iso K, Casement R, Munoz i Ordono M, Nakasone MA, Sathe G, Schatz C, Peters H, Doward M, Kainacher L, Cowan AD, Ciulli A, Winter GE
To Be Published