EMD-54532
Cryo-EM structure of Gephyrin in complex with Darpin 27F3, revealing linker-E domain interactions
EMD-54532
Single-particle3.12 Å
Deposition: 24/07/2025Map released: 24/06/2026
Last modified: 24/06/2026
Sample Organism:
Rattus norvegicus,
synthetic construct
Sample: Gephyrin in complex with Darpin 27F3 partner
Fitted models: 9s3f
Deposition Authors: Ortiz-Lopez D
,
Hove T,
Schindelin H ,
Boettcher B
Sample: Gephyrin in complex with Darpin 27F3 partner
Fitted models: 9s3f
Deposition Authors: Ortiz-Lopez D
,
Hove T,
Schindelin H ,
Boettcher B
Cryo-EM structures of higher order Gephyrin oligomers reveal principles of inhibitory postsynaptic scaffold organization.
Ortiz-Lopez D ,
Hove TT ,
Huhn C ,
Camuso S ,
van Gen Hassend PM ,
Sander B,
Campbell BFN ,
Tyagarajan SK ,
Pluckthun A ,
Specht CG ,
Maric HM ,
Bottcher B ,
Schindelin H
(2026) Nat Commun , 17
,
Hove TT ,
Huhn C ,
Camuso S ,
van Gen Hassend PM ,
Sander B,
Campbell BFN ,
Tyagarajan SK ,
Pluckthun A ,
Specht CG ,
Maric HM ,
Bottcher B ,
Schindelin H
(2026) Nat Commun , 17
Grant Support:
- German Research Foundation (DFG): 232550447 (Germany)
- German Research Foundation (DFG): 456578072 (Germany)
- German Research Foundation (DFG): 359471283 (Germany)
- German Research Foundation (DFG): 525040890 (Germany)