Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-54402
Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils
EMD-54402
Helical reconstruction3.8 Å
Deposition: 15/07/2025Map released: 30/07/2025
Last modified: 24/12/2025
Sample Organism:
Homo sapiens
Sample: Alpha-synuclein fibril purified from the brain of a 1B-injected M83+/- mouse
Fitted models: 9rzf
Deposition Authors: van den Heuvel L
,
Burger D ,
Kashyrina M,
de La Seigliere H ,
Lewis AJ,
De Nuccio F,
Mohammed I,
Verchere J,
Feuillie C,
Berbon M,
Arotcarena M,
Retailleau A ,
Bezard E ,
Canron M,
Meissner WG ,
Loquet A ,
Bousset L ,
Poujol C ,
Nilsson KPR,
Laferriere F ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
Sample: Alpha-synuclein fibril purified from the brain of a 1B-injected M83+/- mouse
Fitted models: 9rzf
Deposition Authors: van den Heuvel L
,
Burger D ,
Kashyrina M,
de La Seigliere H ,
Lewis AJ,
De Nuccio F,
Mohammed I,
Verchere J,
Feuillie C,
Berbon M,
Arotcarena M,
Retailleau A ,
Bezard E ,
Canron M,
Meissner WG ,
Loquet A ,
Bousset L ,
Poujol C ,
Nilsson KPR,
Laferriere F ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
Synthetic alpha-synuclein fibrils replicate in mice causing MSA-like pathology.
Burger D ,
Kashyrina M,
van den Heuvel L ,
de La Seigliere H ,
Lewis AJ,
De Nuccio F,
Mohammed I,
Verchere J,
Feuillie C,
Berbon M,
Arotcarena ML,
Retailleau A ,
Bezard E ,
Canron MH,
Meissner WG ,
Loquet A ,
Bousset L ,
Poujol C ,
Nilsson KPR,
Laferriere F ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
(2025) Nature , 648 , 409 - 417
,
Kashyrina M,
van den Heuvel L ,
de La Seigliere H ,
Lewis AJ,
De Nuccio F,
Mohammed I,
Verchere J,
Feuillie C,
Berbon M,
Arotcarena ML,
Retailleau A ,
Bezard E ,
Canron MH,
Meissner WG ,
Loquet A ,
Bousset L ,
Poujol C ,
Nilsson KPR,
Laferriere F ,
Baron T ,
Lofrumento DD,
De Giorgi F,
Stahlberg H ,
Ichas F
(2025) Nature , 648 , 409 - 417
Grant Support:
- Swiss National Science Foundation: IC00I0L-231578 (Switzerland)
- Agence Nationale de la Recherche (ANR): ANR-24-CE93-0003 (France)