EMD-54359

Single-particle
3.52 Å
EMD-54359
3D View Gallery
Deposition: 10/07/2025
Map released: 03/06/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54359
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9rx6 summary report (pdf.gz) Map and 9rx6 FULL report (pdf.gz)
EMICSS annotations (xml)

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit, composite map processed with CryoTEN.

EMD-54359

Single-particle
3.52 Å
EMD-54359
3D View Gallery
Deposition: 10/07/2025
Map released: 03/06/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Mutant human VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202/VPS15/BECLIN1/UVRAG) bound to RAB5A-GTP (C19S, C63S, Q79L) on the VPS15 subunit
Fitted models: 9rx6

Deposition Authors: Spokaite S, Ohashi Y, Dessus AN, Bourguet M, Williams RL
A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution
Spokaite S, Ohashi Y, Bourguet M, Dessus AN, Williams RL
(2026) eLife
DOI: doi:10.7554/eLife.110040.3
ISSN: 2050-084X