EMD-54215

Single-particle
3.42 Å
EMD-54215
3D View Gallery
Deposition: 01/07/2025
Map released: 08/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54215

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9rsc summary report (pdf.gz) Map-9rsc FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Ternary complex of an improved charged molecular glue degrader ZZ2-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26

EMD-54215

Single-particle
3.42 Å
EMD-54215
3D View Gallery
Deposition: 01/07/2025
Map released: 08/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ZZ2-SO2H-induced complex between YPEL5-CTLH E3 ligase and the first bromodomain (BD1) of BRD4
Fitted models: 9rsc

Deposition Authors: Chrustowicz J, Schulman BA
Charged molecular glue discovery enabled by targeted degron display.
Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Slabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS
(2026) Nat Chem Biol
PUBMED: 41942733
DOI: doi:10.1038/s41589-026-02182-5
ISSN: 1552-4469