EMD-53527

Helical reconstruction
2.8 Å
EMD-53527
3D View Gallery
Deposition: 30/04/2025
Map released: 11/06/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53527

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9r2f summary report (pdf.gz) Map-9r2f FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Tau filaments seeded by AD homogenate using 0N3R C322A

EMD-53527

Helical reconstruction
2.8 Å
EMD-53527
3D View Gallery
Deposition: 30/04/2025
Map released: 11/06/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Microtubule associate tau protein assembled into an amyloid filament
Fitted models: 9r2f

Deposition Authors: Lovestam S , Scheres HWS
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau.
Santambrogio A, Lovestam S , Metrick the Second MA , Lohr T , Xu P, Gallagher NCT, Ghetti B, Caughey B, Scheres SHW , Vendruscolo M
(2025) FEBS Lett , 599 , 2768 - 2778
PUBMED: 41026859
DOI: doi:10.1002/1873-3468.70141
ISSN: 0014-5793
ASTM: FEBLAL
Grant Support: