EMD-53486

Single-particle
3.1 Å
EMD-53486
3D View Gallery
Deposition: 24/04/2025
Map released: 11/02/2026
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53486

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9r0o summary report (pdf.gz) Map-9r0o FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of rat SLCO2A1 bound to tolcapone.

EMD-53486

Single-particle
3.1 Å
EMD-53486
3D View Gallery
Deposition: 24/04/2025
Map released: 11/02/2026
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Rattus norvegicus
Sample: SLCO2A1 protein in detergent-lipid micelle bound to tolcapone drug.
Fitted models: 9r0o

Deposition Authors: Deme JC , Joshi C , Lea SM , Newstead S
Structural basis for prostaglandin and drug transport via SLCO2A1.
Joshi C , Deme JC , Nakamura Y , Hsu WT, Goult JD, Kato T, Parker JL , Biggin PC , Lea SM , Nakanishi T , Newstead S
(2026) Nat Commun , 17
PUBMED: 41862483
DOI: doi:10.1038/s41467-026-70227-3
ISSN: 2041-1723
Grant Support: