EMD-53417
Human UPF1 in complex with the histone stem loop RNA
EMD-53417
Single-particle3.6 Å
Deposition: 14/04/2025Map released: 03/12/2025
Last modified: 21/01/2026
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Upf1
Fitted models: 9qwn
Deposition Authors: Machado de Amorim A, Loll B
,
Hilal T ,
Chakrabarti S
Sample: Upf1
Fitted models: 9qwn
Deposition Authors: Machado de Amorim A, Loll B
,
Hilal T ,
Chakrabarti S
Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay.
Machado de Amorim A,
Xue G,
He W ,
Dittmers T ,
Lewandowski S ,
Perez-Borrajero C ,
Bethmann J,
Mateva N,
Krage C,
Nandana V ,
Loll B ,
Hilal T ,
Hennig J ,
Urlaub H ,
Marzluff WF ,
Chakrabarti S
(2026) Nat Commun , 17 , 155 - 155
,
Dittmers T ,
Lewandowski S ,
Perez-Borrajero C ,
Bethmann J,
Mateva N,
Krage C,
Nandana V ,
Loll B ,
Hilal T ,
Hennig J ,
Urlaub H ,
Marzluff WF ,
Chakrabarti S
(2026) Nat Commun , 17 , 155 - 155
Grant Support:
- German Research Foundation (DFG): CH1245/5-1, CH1245/6-1 (Germany)
- German Research Foundation (DFG): INST 335/589-1 (Germany)
- German Research Foundation (DFG): INST 335/590-1 (Germany)
- German Research Foundation (DFG): INST 335/590-1 (Germany)
- German Research Foundation (DFG): (INST 130/1014-1 (Germany)
- EIPOD fellowship under Marie Sklodowska-Curie Actions COFUND: 664726 (Germany)