EMD-53004

Single-particle
2.83 Å
EMD-53004
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Deposition: 04/03/2025
Map released: 13/05/2026
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-53004
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9qc6 summary report (pdf.gz) Map and 9qc6 FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)

EMD-53004

Single-particle
2.83 Å
EMD-53004
3D View Gallery
Deposition: 04/03/2025
Map released: 13/05/2026
Last modified: 13/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)
Fitted models: 9qc6

Deposition Authors: Shilliday F, Maia de Oliveira T, Gancedo-Rodrigo M
A molecular stabiliser of an inhibitory eIF2B-eIF2( alpha P) complex activates the Integrated Stress Response.
Shilliday F, Gancedo-Rodrigo M, George G, Aibara S, Adhikari S, Ashraf SN, Barrey EJ, Centrella PA, Crowther D, Dickson P, Gikunju D, Guie MA, Guilinger JP, Gunnarsson A, Harding HP, Hupp CD, Jetson R, Keefe AD, Kim JM, Lewis RJ, Maia de Oliveira T, Le-Marshall J, Narayanan U, Nugai KA, Petrovic D, Rivers E, Ron D, Stringfellow D, Syson K, Ward L, Yeoman JTS, Yu Y, Zhang Y, Zyryanova A, Baker DJ, Breccia P, Linley JE
(2026) Nat Commun
PUBMED: 42091608
DOI: doi:10.1038/s41467-026-72688-y
ISSN: 2041-1723
Grant Support: