EMD-52824

Single-particle
2.73 Å
EMD-52824
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Deposition: 14/02/2025
Map released: 04/06/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-52824
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ic1 summary report (pdf.gz) Map and 9ic1 FULL report (pdf.gz)
EMICSS annotations (xml)

Chimeric mitochondrial DNA polymerase gamma ternary complex (hAmB) in replication conformer

EMD-52824

Single-particle
2.73 Å
EMD-52824
3D View Gallery
Deposition: 14/02/2025
Map released: 04/06/2025
Last modified: 04/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens, synthetic construct
Sample: Chimeric mitochondrial DNA polymerase gamma ternary complex (hAmB) in replication conformer
Fitted models: 9ic1

Deposition Authors: Valenzuela S , Falkenberg M
Modelling POLG mutations in mice unravels a critical role of POL gamma Beta in regulating phenotypic severity.
Corra S, Zuppardo A , Valenzuela S , Jenninger L, Cerutti R, Sillamaa S , Hoberg E, Johansson KAS , Rovsnik U, Volta S, Silva-Pinheiro P , Davis H, Trifunovic A , Minczuk M , Gustafsson CM , Suomalainen A , Zeviani M, Macao B , Zhu X , Falkenberg M , Viscomi C
(2025) Nat Commun , 16 , 4782 - 4782
PUBMED: 40404629
DOI: doi:10.1038/s41467-025-60059-y
ISSN: 2041-1723
Grant Support: