Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-52755
Cryo-EM structure of Shigella flexneri LptDE bound by a Bicyclic peptide molecule (Compound 13)
EMD-52755
Single-particle2.86 Å
Deposition: 06/02/2025Map released: 15/10/2025
Last modified: 05/11/2025
Sample Organism:
Shigella flexneri,
synthetic construct
Sample: S. flexneri LPS assembly complex LptDE bound to Bicyclic molecule Compound 13
Fitted models: 9i98
Deposition Authors: Allyjaun S
,
Newman H ,
Dunbar E,
Hardwick SW,
Chirgadze DY,
van den Berg B,
Hubbard J
Sample: S. flexneri LPS assembly complex LptDE bound to Bicyclic molecule Compound 13
Fitted models: 9i98
Deposition Authors: Allyjaun S
,
Newman H ,
Dunbar E,
Hardwick SW,
Chirgadze DY,
van den Berg B,
Hubbard J
High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM.
Allyjaun S ,
Dunbar E,
Hardwick SW,
Newell S ,
Holding F ,
Rowland CE ,
St Denis MA ,
Pellegrino S ,
Arruda Bezerra G ,
Bournakas N,
Chirgadze DY,
Cooper L,
Paris G ,
Lewis N,
Brown P,
Skynner MJ ,
Dawson MJ,
Beswick P,
Hubbard J,
van den Berg B,
Newman H
(2025) J Med Chem , 68 , 21144 - 21155
,
Dunbar E,
Hardwick SW,
Newell S ,
Holding F ,
Rowland CE ,
St Denis MA ,
Pellegrino S ,
Arruda Bezerra G ,
Bournakas N,
Chirgadze DY,
Cooper L,
Paris G ,
Lewis N,
Brown P,
Skynner MJ ,
Dawson MJ,
Beswick P,
Hubbard J,
van den Berg B,
Newman H
(2025) J Med Chem , 68 , 21144 - 21155
Grant Support:
- Medical Research Council (MRC, United Kingdom): U-016275 IAA-CiC (United Kingdom)
- Innovate UK: 10086683 (United Kingdom)