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EMD-52754
Cryo-EM structure of Shigella flexneri LptDE in complex with a Bicyclic Peptide binder (Compound 12)
EMD-52754
Single-particle2.48 Å
Deposition: 06/02/2025Map released: 15/10/2025
Last modified: 05/11/2025
Sample Organism:
Shigella flexneri,
synthetic construct
Sample: Shigella flexneri LptDE in complex with Bicyclic Peptide Binder (Compound 6)
Fitted models: 9i97
Deposition Authors: Allyjaun S
,
Dunbar E,
Hardwick SW,
Chirgadze DY,
Hubbard J,
van den Berg B,
Newman H
Sample: Shigella flexneri LptDE in complex with Bicyclic Peptide Binder (Compound 6)
Fitted models: 9i97
Deposition Authors: Allyjaun S
,
Dunbar E,
Hardwick SW,
Chirgadze DY,
Hubbard J,
van den Berg B,
Newman H
High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM.
Allyjaun S ,
Dunbar E,
Hardwick SW,
Newell S ,
Holding F ,
Rowland CE ,
St Denis MA ,
Pellegrino S ,
Arruda Bezerra G ,
Bournakas N,
Chirgadze DY,
Cooper L,
Paris G ,
Lewis N,
Brown P,
Skynner MJ ,
Dawson MJ,
Beswick P,
Hubbard J,
van den Berg B,
Newman H
(2025) J Med Chem , 68 , 21144 - 21155
,
Dunbar E,
Hardwick SW,
Newell S ,
Holding F ,
Rowland CE ,
St Denis MA ,
Pellegrino S ,
Arruda Bezerra G ,
Bournakas N,
Chirgadze DY,
Cooper L,
Paris G ,
Lewis N,
Brown P,
Skynner MJ ,
Dawson MJ,
Beswick P,
Hubbard J,
van den Berg B,
Newman H
(2025) J Med Chem , 68 , 21144 - 21155
Grant Support:
- Innovate UK: (United Kingdom)
- Medical Research Council (MRC, United Kingdom): (United Kingdom)